Thursday 12 May 2016

Xist Gene



Xist gene (X-inactive specific transcript) is an RNA gene, and is affiliated with the non-coding RNA class. Diseases associated with Xist gene are x-inactivation, familial skewed or craniofrontnasal dysplasia. The Xist RNA is expressed on the inactive chromosome rather than the active one. It is formed in a way resembling the mRNAs. X chromosomes without the Xist gene will not be inactivated, however duplication of it on another chromosome results in inactivation of that chromosome. 

Function:

X inactivation is developed early in mammalian females that transcriptionally silence one of the X chromosomes, which results in dosage equivalence in males and females. The process depends on multiple factors, such as the region of chromosome X which is also called the X inactivation centre (XIC). The XIC compromises sever non coding and protein-coding genes .Xis gene was the first gene to be identified with the X inactivation Centre. This gene is expressed solely from the XIC of the inactive X chromosome, and is needed for the spread of the X-inactivation. 
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5 comments:

  1. Anonymous12 May 2016 at 01:36

    How can Xist be used in order to treat chromosome disorders?
    What happens to the female more specifically when they have the Xist gene?
    Can the Xist gene be used to silence other chromosomes, other then the X chromosome.

    ReplyDelete
  2. Anonymous12 May 2016 at 01:44

    1) What are familial skewed and craniofrontnasal dysplasia?
    2) How does the Xist gene silence chromosomes?
    3) How can the Xist gene be used to treat chromosome disorders?

    ReplyDelete
  3. Anonymous12 May 2016 at 01:46

    1. How can you use Xist to treat chromosome disorders?
    2. How are the XIC and the Xis different?
    3. How does the silencing of the chromosome work?

    ReplyDelete
  4. Anonymous12 May 2016 at 01:49

    Q1: What does it mean to 'transcriptionally silence' a chromosome?

    ReplyDelete
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