Xist gene and how it relates to chromosomal disorders?
Xist gene- X inactive specific transcript
Xist gene- X inactive specific transcript
Xist is an RNA gene on the X chromosome of the placental mammals that acts as a major effector of the X inactivation process. It is a component of the Xic - X-chromosome inactivation centre - along with two other RNA genes (Jpx and Ftx) and two protein genes (Tsx andCnbp2). The Xist RNA, a large transcript, is on the inactive chromosome and not on the active one. However, it remains untranslated. It has been suggested that this RNA gene evolved at from a protein coding gene that became a pseudogene.
Some new studies have shown that it may help into chromosomal disorder treatment.
My questions:
ReplyDelete1. What does it mean if this gene is an inactive specific transcript?
2. When you say that it may help chromosomal disorder treatment, do you mean any chromosomal disorders or does this only apply to a few specific ones?
3. You stated that it is located on the X chromosome of the placental mammals, this means only females right?
Why can Xist help chromosome disorders?
ReplyDeleteWhat does it mean if this gene is a inactive specific transcription?
Can the Xist chromosome be used in order to silence other chromosomes other then the x chromosome?
Why can Xist help chromosome disorders?
ReplyDeleteWhat does it mean if this gene is a inactive specific transcription?
Can the Xist chromosome be used in order to silence other chromosomes other then the x chromosome?
1. Can this treatment help in all chromosomal disorders ?
ReplyDelete2. What does it mean if the gene is in a inactive specific transcription ?
3. Is it located on the X chromosome of both males and females ?