Thursday 12 May 2016

Xist Gene


The Xist gene is used by the body to silence one X chromosome, in a pair of homologous X chromosomes. Xist is a RNA gene, which comes from the splicing of non-coding RNA (which don’t code for proteins).The Xist gene will silence an X chromosome in female mammals so that the dosage between males and females are equal. The process of gene inactivation begins at the X inactivation center, where the Xist gene is located.
Down syndrome is caused by an extra 21 chromosome in the body, also known as trisomy 21. Due to the accumulated information about the Xist gene, and its effects, scientists believe they could silence the extra chromosome with the Xist gene. An experiment performed by Jeanne Lawrence showed that the Xist gene could be used to silence the extra 21 chromosome (Chr21).
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4 comments:

  1. Anonymous12 May 2016 at 01:45

    My questions:
    1. How was this XIST gene discovered in the first place?
    2. Is it specific to chromosomal disorders like trisomy 21 where there is an extra chromosome only?
    3. What is the scientific name for the XIST gene?

    ReplyDelete
  2. Anonymous12 May 2016 at 01:47

    How was the experiment performed?
    How does it silence the x chromosome?
    Is there anything else in the x inactivation centre?

    ReplyDelete
  3. Anonymous12 May 2016 at 05:34

    Questions for: (can't post it on their blogs)
    Ben-What is the Xist gene, or how is it created?
    -Has the Xist gene been used successfully at silencing other chromosomes?
    Charlotte-How were the scientists able to discover the effects of the Xist gene, what devices did they use?

    ReplyDelete
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